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A Brief Guide into NeuroQuant

NeuroQuant is software that evaluates brain magnetic resonance imaging (MRI) to enhance the early diagnosis and treatment of Alzheimer’s disease, dementia, multiple sclerosis, traumatic brain injury, and epilepsy. The technique precisely analyzes brain atrophy (or wastage) by measuring the hippocampus and other brain structures that often waste away when a patient presents certain conditions affecting the brain. The hippocampus, found in the brain’s temporal lobe, is associated with human learning and memory. NeuroQuant MRI also helps the physician to detect and monitor how certain diseases progress.

NeuroQuant matches the patient’s brain MRI to a database cleared by the US FDA, of people of similar sex, skull size, and sex who have healthy brains. The procedure can help uncover early signs of Alzheimer’s disease for patients who experience mild cognitive impairment. According to research, there is a correction between the volume of the hippocampus and the beginning of Alzheimer’s disease. People with smaller hippocampus are four times more likely to have Alzheimer’s in the future than those with normal size hippocampus. Healthy individuals only experience about 1% of hippocampus shrinkage every year, compared to about 5 % each year for those with Alzheimer’s.

With the help of the NeuroQuant technology, the physicians can get the “baseline” of the disease as the basis of their study, and perform ongoing evaluations to monitor changes in brain atrophy over time. This is a great way to identify whether the disease is progressing and the rate at which is doing so. The study can also help to evaluate treatment and identify patients who are very likely to gain from aggressive intervention.

While patients with normal volume of the brain cannot exclude dementia, those who are concerned about mild but progressive memory loss may be reassured by normal range reports after going through the NeuroQuant test.

Benefits of NeuroQuant

  • Quantify information: it allows patients to augment their clinical impression with objective, volumetric information and color-coded images of structures of the brain.
  • Save time: automatic image segmentation from radiographic images can be assessed in PACS within 5 to 7 minutes.
  • Track progression over time: once the patient’s ID is in the system, the NeuroQuant extracts prior data to conduct progressive multi-time point assessments to evaluate brain structure size changes overtime – all shown on the same report
  • Detect and plan earlier: Early detection of neurodegeneration aids in treatment and lifestyle planning for patients.

Change visualization output: this offers a precise comparison of two 3D T1 scans and displays the volumetric changes between time points.

How it works

The NeuroQuant test is a non-invasive pain-free process for obtaining 3D measurements of the brain. The analysis starts with a traditional brain magnetic resonance imaging, but the software later processes the information from the MRI exam to identify and segment the various brain structures. NeuroQuant computes accurate measurements of their volume by monitoring the densities, surface areas and other aspects of these segments. The doctor then matches the amount to established norms based on cranial volume, sex, and age to determine the parts of the brain that are asymmetrical, atrophied or deformed.

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